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Related Experiment Videos

Double peak sensory responses at submaximal stimulation.

Irene Aprile1, Erik Stålberg, Pietro Tonali

  • 1Institute of Neurology, Università Cattolica, Rome, Italy. i.aprile@rm.unicatt.it

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
|February 1, 2003
PubMed
Summary

The double peak sensory response in nerve conduction studies likely represents stimulation at both the cathode and anode. This finding helps clarify the physiological basis of this specific sensory response.

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Area of Science:

  • Neuroscience
  • Electrophysiology

Background:

  • Sensory nerve conduction studies are crucial for diagnosing neurological disorders.
  • A double peak sensory response in these studies requires further physiological explanation.

Purpose of the Study:

  • To investigate the physiological conditions leading to a double peak sensory response.
  • To elucidate the significance of this distinct sensory response pattern.

Main Methods:

  • Conventional orthodromic sensory nerve conduction studies were conducted on 14 healthy subjects.
  • Median and ulnar nerves were stimulated submaximally, with variations in stimulus strength, polarity, electrode position, and local anesthesia.

Main Results:

  • Moving the cathode and anode distally resulted in corresponding distal movement of the first and second peaks.

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  • Anodal stimulation proved ineffective following local skin anesthesia.
  • The observed effects were consistent across conventional and reversed electrode placements.

    • Conclusions:

    • The double response appears to originate from stimulation at the cathode and anode sites.
    • The occurrence of a double response necessitates the stimulation of distinct axons under each pole.
    • Superficial anesthesia suggests the cathode directly stimulates the sensory nerve, while the anode primarily activates superficial structures or skin receptors.