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Oxidized lipid depresses canine growth, immune function, and bone formation
John J Turek1, Bruce A Watkins, Ingrid A Schoenlein
1Department of Basic Medical Sciences, School of Veterinary Medicine, Purdue University, W. Lafayette, IN 47907, USA. turekj@purdue.edu
The Journal of Nutritional Biochemistry
|February 1, 2003
Summary
Dietary oxidized lipids negatively impact canine growth, antioxidant levels, and immune function. Even moderate oxidation levels showed adverse effects, suggesting dogs may be a valuable model for human health studies.
Area of Science:
- Veterinary Nutrition
- Oxidative Stress Research
- Immunology
Background:
- Dietary oxidized lipids are linked to increased oxidative stress and disease.
- Previous research has not fully explored the impact of oxidized lipids using a canine model.
Purpose of the Study:
- To evaluate the effects of dietary oxidized lipids on growth, antioxidant status, and immune functions in a canine model.
- To determine if moderate levels of dietary oxidized lipids cause adverse effects.
Main Methods:
- Three groups of coon-hound puppies were fed diets with varying levels of oxidized lipids (<50, 100, and 500 ppm aldehydes) for 16 weeks.
- Growth, serum vitamin E, body fat, bone appositional rate, neutrophil/monocyte oxidative burst capacity, and lymphocyte blastogenesis were assessed.
Main Results:
- Dogs fed high-oxidation diets exhibited reduced weight gain, lower serum vitamin E, decreased body fat, and slower bone appositional rates.
- Immune function was impaired, with reduced neutrophil and monocyte oxidative burst capacity and suppressed lymphocyte blastogenesis.
- Adverse effects were observed even at the medium-oxidation (100 ppm aldehydes) level.
Conclusions:
- Dietary oxidized lipids adversely affect canine growth, antioxidant status, and immune functions.
- Canine models may be suitable for assessing risks associated with dietary oxidized lipids, particularly in young, rapidly growing individuals.
- Moderate levels of dietary oxidized lipids can have significant negative health impacts.