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Candidemia in neonatal intensive care unit.
Indian Journal of Pathology & Microbiology
|February 4, 2003
Summary
Candida glabrata is the most common cause of candidemia in neonatal intensive care units. Risk factors include broad-spectrum antibiotics, parenteral nutrition, and ventilators.
Area of Science:
- Medical Microbiology
- Neonatal Medicine
- Infectious Diseases
Background:
- Candidemia poses a significant threat to neonates in intensive care.
- Understanding causative species and risk factors is crucial for effective management.
Purpose of the Study:
- To identify Candida species responsible for candidemia in a neonatal intensive care unit (NICU).
- To analyze risk factors associated with significant fungemia in neonates.
Main Methods:
- Over a 6-month period, 19 Candida isolates were speciated using standard techniques.
- Antimicrobial susceptibility testing was performed against Amphotericin B, Fluconazole, Ketoconazole, and 5-Flucytosine.
- Risk factors for candidemia were statistically analyzed.
Main Results:
- Candida glabrata was the most prevalent species (42.1%), followed by C. tropicalis (31.6%), C. albicans (21.1%), and C. parapsilosis (5.2%).
- All isolates were susceptible to Amphotericin B; resistance to other agents was noted only in C. glabrata.
- Significant candidemia occurred in 72.6% of neonates.
Conclusions:
- Candida glabrata is a primary cause of candidemia in this NICU population.
- Multiple broad-spectrum antibiotics, total parenteral nutrition, and ventilator use are significant risk factors for candidemia in neonates.