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Anxiety associated with comorbid depression
1Department of Psychiatry, Psychiatrische Universitatsklinik, Munich, Germany. hans-juergen.moeller@psy.med.uni-muenchen.de
The Journal of Clinical Psychiatry
|February 4, 2003
Summary
Benzodiazepines are often prescribed for comorbid anxiety and depression, despite risks. This study examines their efficacy alone versus with antidepressants for these conditions.
Area of Science:
- Psychiatry
- Clinical Psychology
- Pharmacology
Background:
- Historically, mixed depression and anxiety was termed anxious depression.
- Current diagnostic systems (DSM-IV) provide specific criteria for anxiety and depression, necessitating clearer treatment guidelines.
- Benzodiazepines are frequently used alongside antidepressants for comorbid anxiety and depression, despite known risks.
Purpose of the Study:
- To present data on the prevalence, course, and outcomes of comorbid anxiety and depression.
- To compare the efficacy of benzodiazepines used alone versus in combination with antidepressants for anxiety disorders comorbid with depression.
Main Methods:
- Review of data on the prevalence, course, and outcome of comorbid anxiety and depression.
- Comparative analysis of efficacy data from clinical trials involving benzodiazepines (alone and with antidepressants).
Main Results:
- Data on prevalence, course, and outcome of comorbid anxiety and depression are presented.
- Efficacy of benzodiazepines alone and in combination with antidepressants for comorbid anxiety and depression is compared.
Conclusions:
- The study addresses the need for a better understanding of benzodiazepine use in treating anxiety disorders comorbid with depression.
- Findings will inform clinical practice regarding the appropriate use of benzodiazepines in managing complex anxiety and depressive conditions.