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Melatonin increases oestradiol-induced bone formation in ovariectomized rats.
Marta G Ladizesky1, Verónica Boggio, Liliana E Albornoz
1Sección Osteopatías Médicas, Hospital de Clínicas José de San Martín, Facultad de Medicina, Universidad de Buenos Aires, Argentina.
Journal of Pineal Research
|February 4, 2003
Summary
Melatonin restrains bone remodelling in ovariectomized rats, enhancing oestradiol
Area of Science:
- Endocrinology and Bone Metabolism
Background:
- Ovariectomy in rats leads to bone loss and increased body fat.
- Oestradiol therapy is a common treatment for post-menopausal bone loss.
Purpose of the Study:
- To investigate the effects of melatonin on bone metabolism in ovariectomized rats, with or without oestradiol therapy.
- To assess melatonin's impact on bone resorption, formation, and body composition.
Main Methods:
- Ovariectomized rats received melatonin (drinking water) and/or oestradiol (subcutaneous injection) for up to 60 days.
- Measurements included urinary deoxypyridinoline, serum bone alkaline phosphatase, calcium, phosphorus, body weight, and body fat.
- Bone area, bone mineral content, and bone mineral density were assessed using dual-energy X-ray absorptiometry.
Main Results:
- Melatonin and oestradiol treatments reduced bone resorption and increased bone mineral density and content in ovariectomized rats.
- Melatonin enhanced the bone-protective effects of oestradiol, particularly in ovariectomized rats.
- Both treatments counteracted ovariectomy-induced increases in body fat.
Conclusions:
- Melatonin treatment restrains bone remodelling in ovariectomized rats.
- Melatonin's bone-protective effects are dependent on adequate oestradiol levels and augment oestradiol's efficacy.
- Melatonin also counter-regulates ovariectomy-induced body fat increase.