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[Immunoregulation of IL-2 in Trichinella-infected mice]
1Department of Cell Biology, Capital University of Medical Sciences, Beijing 100054.
Aim:
To study the immunoregulation of IL-2 in Trichinella-infected mice.
Methods:
Mice infected respectively with HL strain and AM strain larvae of Trichinella spiralis were treated i.p. with IL-2 from the second day postinfection for 3 days. Serum IgG antibody levels were determined by ELISA and the infection capacity was determined using reproductive capacity index (RCI).
Results:
In HL, higher dosage of IL-2 injection induced lower RCI and showed apparent anti-Trichinella effect. In AM, both low and high dose of IL-2 had no measurable effect on RCI, however, high dose of IL-2 reduced the infectivity of newborn larvae.
Conclusion:
IL-2 exhibits apparent suppressive effect on the infectivity of T. spiralis of HL strain.