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Related Concept Videos

DNA Microarrays02:34

DNA Microarrays

21.2K
Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...
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Hybridoma Technology01:31

Hybridoma Technology

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Hybridoma technology is used for the large-scale production of monoclonal antibodies. Monoclonal antibodies bind to only a single antigenic determinant or epitope. Such antibodies are used in research, diagnostics, and disease therapy. The hybridoma technology established in 1975 by Georges Köhler and Cesar Milstein was awarded the Nobel Prize in Medicine in 1984 for revolutionizing research and therapy.
Hybridoma Selection
Commonly used fusion techniques — electroporation,...
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DNA Isolation01:34

DNA Isolation

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DNA from cells is required for many biotechnology and research applications, such as molecular cloning. To remove and purify DNA from cells, researchers use various methods of DNA extraction. While the specifics of different protocols may vary, some general concepts underlie the process of DNA extraction.
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DNA-only Transposons02:57

DNA-only Transposons

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DNA-only transposons are called autonomous transposons since they code for the enzyme transposase that is required for the transposition mechanism. Insertion of transposons can alter gene functions in multiple ways. They can mutate the gene, alter gene expression by introducing a novel promoter or insulator sequence, introduce new splice sites, and change the mRNA transcripts produced, or remodel chromatin structure.
The donor site from where the transposon is excised is either degraded or...
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Health Information Technology and Healthcare Information System01:30

Health Information Technology and Healthcare Information System

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Health Information Technology (HIT)
Health Information Technology, commonly called HIT, integrates advanced information systems and technology in healthcare settings. Its primary functions include:
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DNA Topoisomerases02:02

DNA Topoisomerases

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Topoisomerases are enzymes that relax overwound DNA molecules during various cell processes, including DNA replication and transcription. These enzymes regulate positive and negative DNA supercoiling without changing the nucleotide sequence. DNA overwinding in a clockwise direction results in positively supercoiled DNA, whereas underwinding in a counterclockwise direction produces negatively supercoiled DNA.
Types and Mechanism of action
Topoisomerases are divided into two main types. ...
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ampliPHOX Colorimetric Detection on a DNA Microarray for Influenza
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ampliPHOX Colorimetric Detection on a DNA Microarray for Influenza

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[Application of DNA Microarray Technology in Human Trypanosomiasis Research].

Mu-xin Chen, Jia-xu Chen

    Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi = Chinese Journal of Parasitology & Parasitic Diseases
    |August 28, 2018
    PubMed
    Summary
    This summary is machine-generated.

    DNA microarray technology offers high-throughput analysis for biological research. This review highlights its applications in studying human trypanosomiasis, including parasite-host interactions and developing new treatments.

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    Area of Science:

    • Molecular Biology
    • Parasitology
    • Genomics

    Background:

    • Trypanosomiasis is a significant human blood parasitic disease.
    • DNA microarray enables high-throughput measurement of biological parameters.
    • Advanced molecular biological techniques are crucial for disease research.

    Purpose of the Study:

    • To review the applications of DNA microarray in human research on Trypanosoma brucei and Trypanosoma cruzi.
    • To update on the utility of DNA microarray in parasitology.
    • To explore the role of DNA microarray in understanding parasite-host interactions.

    Main Methods:

    • Literature review of studies utilizing DNA microarray in trypanosome research.
    • Analysis of applications in genome studies, vaccine screening, and drug development.
    • Focus on research concerning Trypanosoma brucei and Trypanosoma cruzi.

    Main Results:

    • DNA microarray is a valuable tool for high-throughput analysis of trypanosome genomes.
    • The technique aids in studying parasite-host interactions.
    • DNA microarray facilitates vaccine screening and drug development for trypanosomiasis.

    Conclusions:

    • DNA microarray technology significantly advances human research on trypanosomiasis.
    • Its application is crucial for understanding Trypanosoma brucei and Trypanosoma cruzi.
    • This technique supports the development of novel diagnostics and therapeutics.