Metastatic uveal melanoma: diagnosis and treatment. A literature review

In the past three decades many efforts were done to improve the visual prognosis of patients with uveal melanoma. However, mortality has remained unchanged. The systemic prognosis depends on the size and other characteristics of the lesion. It is not affected by the choice of local treatment. This suggests dissemination at an early stage. The failure to improve survival is caused by difficulties in early detection of metastases and the limited susceptibility of these metastases to systemic therapies.