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Modelling of carbonic anhydrase inhibitory activity of sulfonamides using molecular negentropy
Vijay K Agrawal1, Padmakar V Khadikar
1QSAR and Computer Chemical Laboratories, A.P.S. University, Rewa 486 003, India. vijay-agrawal@lycos.com
Bioorganic & Medicinal Chemistry Letters
|February 5, 2003
Abstract:
The present paper deals with the modelling of carbonic anhydrase inhibitory activity of sulfonamides using molecular negentropy (N). Excellent results are obtained in multiple regression analysis upon introduction of indicator parameters. The results are critically discussed on the basis of statistical data obtained from regression analysis.