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[Detection of telomerase activity in gastric cancer and adjacent tissues]
1Department of Abdominal Surgery and Centre of Tumor Biology, Cancer Hospital, CAMS and PUMC, Beijing 100021.
Objective:
To study the telomerase activity in chinese gastric cancer and their adjacent tissues and to explore the possibility of telomerase as a tumor biological marker.
Methods:
Telomerase activity was analyzed in 42 primary gastric cancers and their adjacent tissues and 1 benign gastric lesion by a PCR-based telomerase repeat amplification protocol assay.
Results:
The result showed 88.1% (37/42) gastric cancerous specimens displayed telomerase activity. However, only 2 of 42 tissue samples adjacent to the gastric cancer showed telomerase activity. However our results indicated that 1 benign gastric lesion sample expressed telomerase activity.
Conclusions:
The results indicated that the detection of telomerase activity might be a useful method in the diagnosis of gastric cancer.