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[Studies on apoptosis and its induction in Schistosoma japonicum]

W S Wang1, Y L Li

  • 1Department of Parasitology, Tongji Medical University, Wuhan 430030.

Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi = Chinese Journal of Parasitology & Parasitic Diseases
|February 6, 2003
PubMed
Abstract

Insights

Apoptosis, programmed cell death, was induced in Schistosoma japonicum (S. japonicum) adult cells and eggs using chemical and physical agents. This study observed the occurrence of apoptosis in parasite cells, offering insights into its mechanisms.

Area of Science:

  • Parasitology
  • Cell Biology
  • Molecular Biology

Context:

  • Schistosoma japonicum (S. japonicum) is a parasitic flatworm causing schistosomiasis.
  • Understanding apoptosis in S. japonicum is crucial for developing novel control strategies.

Purpose:

  • To investigate the induction and occurrence of apoptosis in S. japonicum adult cells and eggs.
  • To identify chemical and physical agents capable of triggering programmed cell death in this parasite.

Summary:

  • Adult S. japonicum cells treated with H2O2, dexamethasone, or cyclosporin A exhibited DNA laddering characteristic of apoptosis.
  • S. japonicum eggs treated at 42°C also showed DNA laddering, indicating apoptosis induction.
  • In situ end labeling confirmed apoptosis in treated adult cells and identified positive fluorescence in some control and vehicle-treated groups.

Impact:

  • Demonstrates that apoptosis can be induced in S. japonicum by various agents.
  • Provides a foundation for exploring targeted apoptosis induction as a potential anti-parasitic therapy.
  • Contributes to the fundamental understanding of cell death pathways in parasitic organisms.

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