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Did quadruplex DNA play a role in the evolution of the eukaryotic linear chromosome?
Haribabu Arthanari1, Philip H Bolton
1Chemistry Department, Wesleyan University, Middletown, CT 06459, USA.
Mini Reviews in Medicinal Chemistry
|February 7, 2003
Abstract:
The current evidence on prokaryotic linear chromosomes, the eukaryotes that do not use telomerase and quadruplex DNA has been considered. This has lead to the suggestion that quadruplex DNA may have played a role in the evolution of the protection linear chromosomes rather than in overcoming the end replication problem.