Related Experiment Video
Updated: Aug 8, 2026
09:19
NMR-Based Fragment Screening in a Minimum Sample but Maximum Automation Mode
Published on: June 4, 2021
Fragment screening in focus
Structure (London, England : 1993)
|August 6, 2026
Summary
This article covers advances in fragment screening using X-ray crystallography and Nuclear Magnetic Resonance (NMR). It highlights current challenges and future opportunities, with the Protein Data Bank (PDB) adapting to support this evolving field.
Area of Science:
- Structural biology
- Biochemistry
- Drug discovery
Background:
- Fragment screening is a key method in drug discovery.
- Advances in crystallographic and NMR techniques have improved fragment screening.
- The Protein Data Bank (PDB) is a crucial resource for structural data.
Purpose of the Study:
- To discuss recent advances in fragment screening.
- To identify current challenges and future opportunities in fragment screening.
- To describe how the PDB is adapting to support fragment screening.
Main Methods:
- Crystallographic fragment screening
- Nuclear Magnetic Resonance (NMR) fragment screening
- Data deposition and retrieval from the PDB
Main Results:
- Recent advances in fragment screening techniques have been discussed.
- Key challenges and future opportunities in the field were identified.
- The PDB is evolving to better support fragment screening data.
Conclusions:
- Fragment screening continues to be a vital tool in drug discovery.
- Continued innovation in experimental techniques and data management is essential.
- The PDB plays a critical role in facilitating fragment screening research.
