Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nucleic acids as targets for antitelomerase agents.

Patrizia Alberti1, Laurent Lacroix, Lionel Guittat

  • 1Laboratoire de Biophysique, Muséum National d'Histoire Naturelle, INSERM U 565, CNRS UMR 8646, Paris, France.

Mini Reviews in Medicinal Chemistry
|February 7, 2003
PubMed
Summary

Telomeres shorten with cell division without telomerase. Inhibiting telomerase, active in cancer cells but not most normal cells, offers a promising anticancer strategy, particularly using quadruplex ligands.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Visualizing cellular G-quadruplexes with a bioinspired chemiluminescent probe.

Nucleic acids research·2026
Same author

The presence and impact of G-quadruplexes in plant chloroplast DNA.

BMC plant biology·2026
Same author

High-throughput measurement and prediction of the i-motif DNA stability landscape.

Nucleic acids research·2026
Same author

Archaeal G-quadruplexes: a novel model for understanding unusual DNA/RNA structures across the tree of life.

Nucleic acids research·2026
Same author

Designing an ecofriendly catalyst for a sustainable use of water resources.

National science review·2026
Same author

Pentanucleotide guanine-rich WGGGW repeats, including CANVAS AGGGA repeats, form a variety of noncanonical structures.

Nucleic acids research·2026

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Telomeric DNA shortens with each cell division in cells lacking telomerase, an enzyme essential for replicating chromosomal ends.
  • Telomerase is active in tumor cells but typically absent in most somatic cells.
  • This differential expression makes telomeres and telomerase attractive targets for novel anticancer drug development.

Purpose of the Study:

  • To explore strategies for inhibiting telomerase activity.
  • To focus on targeting the telomere/telomerase nucleic acid component.
  • To emphasize the potential of quadruplex ligands in this inhibition.

Main Methods:

  • Review and presentation of various strategies to inhibit telomerase.
  • Focus on molecular interactions with telomere and telomerase nucleic acid structures.

Related Experiment Videos

  • Special emphasis on the application of quadruplex-specific ligands.

    • Main Results:

    • Identification of distinct strategies for telomerase inhibition.
    • Demonstration of targeting nucleic acid components of the telomere/telomerase complex.
    • Highlighting the efficacy of quadruplex ligands in these inhibitory approaches.

    Conclusions:

    • Inhibiting telomerase presents a viable strategy for cancer therapy.
    • Quadruplex ligands are effective agents for targeting telomere/telomerase nucleic acids.
    • Further development of telomerase inhibitors, especially quadruplex ligands, holds significant therapeutic promise.