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Imino-sugar-based nucleosides.

Vern L Schramm1, Peter C Tyler

  • 1Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

Current Topics in Medicinal Chemistry
|February 7, 2003
PubMed
Summary
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Imino-sugar nucleosides are potent inhibitors of N-ribosyltransferases, mimicking transition states. This review covers synthetic routes and therapeutic potential for imino- and imino-C-nucleosides in treating disorders.

Area of Science:

  • Medicinal Chemistry
  • Biochemistry
  • Organic Synthesis

Background:

  • N-ribosyltransferases are crucial enzymes in biological pathways.
  • Imino-C-nucleoside analogues show potent inhibitory activity against these enzymes.
  • These analogues mimic the ribooxacarbenium ion transition state of N-ribosyltransferases.

Purpose of the Study:

  • To review synthetic routes for imino- and imino-C-nucleosides.
  • To discuss the N-ribosyltransferases targeted by these analogues.
  • To highlight the therapeutic promise of these compounds for various biological disorders.

Main Methods:

  • Literature review of synthetic methodologies for imino- and imino-C-nucleosides.
  • Analysis of the mechanism of action of imino-C-nucleoside analogues.

Related Experiment Videos

  • Case studies illustrating therapeutic applications.

    • Main Results:

    • Challenging synthetic pathways for imino- and imino-C-nucleosides have been developed.
    • Detailed understanding of enzyme-inhibition mechanisms.
    • Demonstrated potential for treating biological disorders.

    Conclusions:

    • Imino-C-nucleoside analogues represent a promising class of therapeutic agents.
    • Further research into their synthesis and application is warranted.
    • These compounds offer a novel strategy for targeting N-ribosyltransferases.