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Menstrual induction with the PGF2alpha-analogue ICI 81008
Prostaglandins
|January 1, 1976
Summary
Menstrual induction using ICI 81008, a PGF2alpha analogue, demonstrated effectiveness in early pregnancy termination. This method showed fewer side effects compared to other prostaglandins, with higher doses yielding better results.
Area of Science:
- Reproductive Medicine
- Pharmacology
Background:
- Menstrual induction (MI) is a method for early pregnancy termination.
- Prostaglandins (PGs) are commonly used for MI.
- ICI 81008 is a novel PGF2alpha analogue studied for MI.
Purpose of the Study:
- To evaluate the safety and efficacy of ICI 81008 for menstrual induction.
- To compare the side effect profile of ICI 81008 with PGF2alpha and PGE2.
Main Methods:
- A pilot study involving 79 volunteers was conducted.
- ICI 81008 was administered into the uterine cavity via a transcervical catheter.
- Doses were escalated from 100-200 mug to 400 mug based on initial safety and efficacy.
- Intrauterine pressure and plasma progesterone levels were monitored.
Main Results:
- At 400 mug, 76% of patients achieved complete abortion and 21% had incomplete abortion.
- ICI 81008 showed fewer side effects than PGF2alpha and PGE2, except for a transient increase in blood pressure.
- Successful treatment correlated with a significant decrease in plasma progesterone.
Conclusions:
- ICI 81008 is an effective agent for menstrual induction with an acceptable side effect profile.
- The drug induces strong uterine contractions, leading to pregnancy termination.
- Further studies are investigating a vaginal delivery system for ICI 81008.