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Anti-diabetes effect of Zn(II)/carnitine complex by oral administration
Yutaka Yoshikawa1, Eriko Ueda, Hiromu Sakurai
1Department of Chemistry, Graduate School of Science, Osaka City University, Japan.
Chemical & Pharmaceutical Bulletin
|February 11, 2003
Abstract:
A novel bis(L-carnitinato)Zn(II) complex, Zn(car)(2)Cl(2), was prepared, and its insulinomimetic and antidiabetic activities were examined. The complex showed a tendency to lower the high blood glucose levels of KK-A(y) mice with type 2 diabetes mellitus when given by oral administration at a dose of 20 mg Zn/kg body weight for 16 d. In addition, the complex improved glucose tolerance ability when examined by the oral glucose tolerance test (1 g glucose/kg body weight).