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Related Experiment Videos

Cryptococcus neoformans myositis without dissemination.

Mamta Sharma1, Riad Khatib, Bruce A Jones

  • 1Department of Medicine, St John Hospital & Medical Center, Detroit, MI 48236, USA.

Scandinavian Journal of Infectious Diseases
|February 13, 2003
PubMed
Summary

This study details a rare case of isolated cryptococcal myositis in a paraspinal muscle of a patient with large B-cell lymphoma. The infection was successfully treated with antifungal therapy, highlighting a localized manifestation of Cryptococcus neoformans.

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Area of Science:

  • Infectious Diseases
  • Mycology
  • Oncology

Background:

  • Cryptococcal myositis is a rare fungal infection affecting skeletal muscles.
  • It is often associated with disseminated cryptococcosis, particularly in immunocompromised individuals.
  • Large B-cell lymphoma is an underlying condition that can increase susceptibility to opportunistic infections.

Observation:

  • A patient with newly diagnosed large B-cell lymphoma presented with isolated cryptococcal myositis of the paraspinal muscle.
  • Muscle biopsy revealed a pure culture of Cryptococcus neoformans and characteristic yeast forms.
  • No evidence of disseminated cryptococcal disease was found at presentation.

Findings:

  • The isolated paraspinal cryptococcal myositis was confirmed through microbiological and histopathological examination.

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  • Systemic antifungal therapy led to a complete resolution of the myositis.
  • A review of five previously reported cases of cryptococcal myositis was included.

    • Implications:

    • This case expands the understanding of localized presentations of cryptococcal infections.
    • It underscores the importance of considering fungal myositis in immunocompromised patients with localized muscle symptoms.
    • Prompt diagnosis and treatment are crucial for favorable outcomes in cryptococcal myositis.