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[Flow injection biamperometric analysis of isoniazid]
1Institute of Analytical Science, Northwest University, Xi'an 710069, China.
Yao Xue Xue Bao = Acta Pharmaceutica Sinica
|February 13, 2003
Summary
A new electrochemical method offers a simple, rapid, and accurate way to determine isoniazid online. This sensitive and selective technique is ideal for direct isoniazid analysis in various settings.
Area of Science:
- Electrochemistry
- Analytical Chemistry
- Biosensing
Context:
- Isoniazid is a crucial drug for tuberculosis treatment.
- Accurate and rapid determination of isoniazid is essential for quality control and therapeutic monitoring.
- Existing methods for isoniazid analysis can be time-consuming or complex.
Purpose:
- To develop a simple, rapid, and accurate electrochemical method for the on-line determination of isoniazid.
- To utilize flow injection biamperometry with platinum electrodes for isoniazid quantification.
- To establish a selective and sensitive analytical technique for isoniazid.
Summary:
- A biamperometric method using two pre-anodized platinum electrodes was developed for isoniazid determination.
- The method relies on the catalytic oxidation of isoniazid and reduction of platinum oxide.
- A linear relationship was observed between current and isoniazid concentration (1.0 x 10(-6)-1.0 x 10(-4) mol.L-1) with good precision (RSD 1.8%).
Impact:
- The developed method is sensitive, selective, and rapid (120 samples/hour).
- It is suitable for on-line, direct determination of isoniazid, simplifying analysis.
- This technique can enhance quality control of pharmaceutical formulations and facilitate therapeutic drug monitoring.