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Sickle cell disease

Jason Fixler1, Lori Styles

  • 1Children's Hospital and Research Center at Oakland, Department of Hematology/Oncology, 747 52nd Street, Oakland, CA 94609, USA.

Pediatric Clinics of North America
|February 13, 2003
PubMed

Insights

Sickle cell disease is a serious genetic blood disorder affecting African-Americans. This review covers current knowledge on sickle cell disease complications and potential treatments for patients.

Area of Science:

  • Hematology
  • Genetics
  • Pediatrics

Background:

  • Sickle cell disease (SCD) is a severe, inherited blood disorder impacting approximately 1 in 600 African Americans.
  • First described in 1910, medical understanding and therapeutic strategies for SCD have significantly advanced.
  • Pediatricians frequently encounter children with SCD, necessitating comprehensive knowledge of the condition.

Purpose of the Study:

  • To provide an updated summary of current knowledge regarding sickle cell disease.
  • To detail the known complications associated with sickle cell disease.
  • To outline potential treatment options for individuals with sickle cell disease.

Main Methods:

  • This article is a review of existing literature on sickle cell disease.
  • It synthesizes current understanding of the disease's pathophysiology and clinical manifestations.
  • Information on complications and treatments is compiled from established medical resources.

Main Results:

  • Sickle cell disease presents with a range of serious complications affecting multiple organ systems.
  • Various treatment modalities exist, aimed at managing symptoms and preventing complications.
  • Ongoing research continues to explore novel therapeutic approaches for SCD.

Conclusions:

  • A thorough understanding of sickle cell disease, its complications, and treatments is crucial for healthcare providers, especially pediatricians.
  • Effective management requires a comprehensive approach addressing the multifaceted nature of the disease.
  • Continued research and clinical advancements offer hope for improved outcomes in sickle cell disease patients.

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