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[Effects of Angelica polysaccharide on blood coagulation and platelet aggregation]
Tiehong Yang1, Min Jia, Qibing Mei
1Faculty of Preclinical Medicine, Fourth Military Medical University, Xi'an 710033.
Objective:
To investigate the effects of angelica polysaccharide (AP) on blood coagulation and platelet aggregation.
Methods:
Infrared turbidimetric method was used to estimate platelet aggregation, active partial thromboplastin time (APTT), prothrombin time (PT) and thrombin time (TT); bleeding time (BT) was measured by cutting the mouse's tail and coagulate time (CT) was measured by dropping the blood on carry sheet glass.
Results:
AP prominently enhanced the platelet aggregation at 5 min, while showed less effects on the maximum platelet aggregation. It also markedly prolonged CT but shortened BT. AP significantly prolonged TT and APTT in dosage of 3 mg/kg and 10 mg/kg, while showed no obvious effect on PT.
Conclusion:
These results suggest that AP has potent anticoagulant and haemostasis effects. The haemostasis effect is related to promoting platelet aggregation.