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[Effects of Pedicularis decora extract on anti-oxidation injury in mice]
Jianxiong Yang1, Meili Gao, Farong Li
1College of Life Science, Shaanxi Normal University, Xi'an 710062.
Objective:
To study the protection effects of Pedicalaris decorm extract on oxidation lesion in mice and the effective components of Pedicalaris decorm.
Methods:
The total extract, BuOH soluble components and water soluble components of Pedicalaris decorm were administered (ig) 15 g.kg-1.d-1 to mice, and the oxidation injury model in mice was induced by i.p. alloxan 180 mg.kg-1. SOD, GSH-Px and LPO in red blood cell and liver, ALT, AST, AKP and r-globulin in serum, LPO and MAO.B in brain, liver index and spleen index were measured.
Results:
All the three Pedicalaris decorm extracts can obviously lower abnormal contents of SOD, GSH-Px, LPO, ALT, AST, AKP, MAO.B and r-globulin induced by alloxa, and obviously improve abnormal decrease of liver index and spleen index.
Conclusion:
Pedicalaris decorm extract can inhibit oxidation lesion in mice. The effects of total extract and BuOH soluble components were better than water soluble components.