[Effect of subtoxic doses of dipterex on guinea pigs]

Chronic experiments were carried out with 62 guinea pigs (31 test and 31 control animals) which were given dipterex orally for 60 days at the rate of 100 mg/kg each. The effect was followed up of dipterex on the bactericidal properties of the blood, the phagocytic activity of some organs of the reticulo-endothelial system, the serum cholinesterase, the alkaline phosphatase, the hemoglobin and hematocrit values of the blood, and the proteinogram of the blood serum. A neglible drop of the gamma-globin fraction of the serum and the phagocytic activity of the immobile cells of the RES of the spleen and liver was found. The hemoglobin content decreased by 13.5 per cent, while the hematocrit value remained unchanged. At the amount given above dipterex suppressed by 50 per cent the activity of the serum cholinesterase, and increased by 36 per cent that of the alkaline phosphatase.