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Facile construction and divergent transformation of polycyclic isoxazoles: direct access to polyketide architectures
Jeffrey W Bode1, Yoshifumi Hachisu, Tomoo Matsuura
1Department of Chemistry, Tokyo Institute of Technology, and CREST, Japan Science and Technology (JST) Corporation, O-okayama, Meguro-ku, Tokyo 152-8551, Japan.
Organic Letters
|February 14, 2003
Abstract:
[reaction: see text] Base-promoted cyclocondensation of C-chloro oximes with cyclic 1,3-diketones affords functionalized isoxazoles in good yield and under convenient reaction conditions. This process enables the synthesis of highly substituted products with notable functional group tolerance. The products obtained are directly converted to a variety of polyketide-derived polycyclic structures including xanthenes, anthracenes, and benzophenones.