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Isoxazole --> benzisoxazole rearrangement promoted cascade reactions affording stereodefined polycycles
Jeffrey W Bode1, Hidehiro Uesuka, Keisuke Suzuki
1Department of Chemistry, Tokyo Institute of Technology, and CREST, Japan Science and Technology (JST) Corporation, O-okayama, Meguro-ku, Tokyo 152-8551, Japan.
Organic Letters
|February 14, 2003
Abstract:
[reaction: see text] A new chemo-, regio-, and stereoselective cascade reaction features a novel isoxazole --> benzisoxazole rearrangement and affords highly functionalized, differentially protected compounds. The products of this reaction are directly converted to a number of complex, structurally diverse polycyclic molecules. These transformations highlight the unique chemistry inherent to readily prepared fused isoxazoles.