[Possible physiological role of the "high molecular weight polyphosphate-polyphosphate phosphohydrolase" system in...

The biosynthesis of polyphosphatase and the system of active transport of glucose is repressed in the cells of Neurospora crassa by glucose at a high concentration. There is a strict correlation between the activity of polyphosphatase and the initial rate of glucose active transport. Both systems are repressed during the growth of the mycelium on a glucose medium and are repaired on a medium without glucose. The latter process is inhibited by cycloheximide. Under various conditions of cultivation, the ratio between the activity of polyphosphatase and the initial rate of active transport of glucose remains close to unity. The experiments with 8-azaadenine have shown that the system of active transport of glucose does not require ATP. A possible physiological role of polyphosphatase in N. crassa is discussed.