In situ co-crystallisation as a tool for low-temperature crystal engineering

Area of Science:

• Materials Science
• Crystallography
• Supramolecular Chemistry

Background:

• Co-crystals are crystalline solids composed of two or more molecular components.
• Low-melting co-crystals offer advantages in processing and applications.
• Crystal engineering aims to design and synthesize crystalline materials with desired properties.

Purpose of the Study:

• To explore in situ co-crystallisation for synthesizing low-melting co-crystals.
• To investigate the use of pyrazine and n-alkyl carboxylic acids in co-crystal formation.
• To demonstrate the versatility of this method for low-temperature crystal engineering.

Main Methods:

• Synthesis of co-crystals through in situ co-crystallisation.
• Single-crystal X-ray diffraction for structural analysis.
• Characterisation of co-crystals formed from pyrazine and n-alkyl carboxylic acids.

Main Results:

• Successful synthesis of a series of low-melting co-crystals.
• Structural elucidation of the co-crystal forms.
• Demonstration of in situ co-crystallisation as an effective technique.

Conclusions:

• In situ co-crystallisation is a powerful and versatile tool for crystal engineering.
• The pyrazine-n-alkyl carboxylic acid system yields low-melting co-crystals.
• This approach facilitates low-temperature crystal design and synthesis.