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Updated: Aug 12, 2026

09:33
Phthalic Acid Ester-Binding DNA Aptamer Selection, Characterization, and Application to an Electrochemical Aptasensor
Published on: March 21, 2018
Non-covalent aptamer decoration promotes THP1-MØ phagocytosis of bacteria by enhancing target proximity
Shizuka Kuchiki1, Maasa Yokomori1, Susumu Muto2
1Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo, 153-8902, Japan. ckeitaro@mail.ecc.u-tokyo.ac.jp.
Abstract:
We report a noncovalent strategy to install cholesterol-conjugated DNA aptamers on THP1-MØ membranes by lipid insertion, thereby increasing target-effector proximity and promoting bacterial phagocytosis.
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