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Updated: Oct 26, 2026

07:06
Continuous Flow Chemistry: Reaction of Diphenyldiazomethane with p-Nitrobenzoic Acid
Published on: November 15, 2017
Integrated continuous flow synthesis enabled by solid-acid micro-packed bed reactors: a four-step sustainable route
Yan Chen1, Shiqiu Song1, Fang Zhao2
1State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China. wpzhu@ecust.edu.cn.
Abstract:
Heterogeneous solid-acid catalysis is integrated into a multi-step continuous-flow platform for pharmaceutical synthesis. This strategy avoids the neutralization steps required for corrosive liquid-acid catalysis, furnishing the target product in good overall yield with improved process sustainability.

