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A diffusion approximation for selection and drift in a subdivided population.

Joshua L Cherry1, John Wakeley

  • 1Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA. cherry@oeb.harvard.edu

Genetics
|February 15, 2003
PubMed
Summary
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Population subdivision impacts genetic diversity. This study shows that while effective population size (N(e)) increases, the effective selection coefficient (s(e)) decreases, keeping allele fixation probabilities stable.

Area of Science:

  • Population Genetics
  • Evolutionary Biology
  • Quantitative Genetics

Background:

  • Population structure significantly influences genetic drift and natural selection.
  • The effect of population subdivision on effective population size (N(e)) is complex and debated.
  • Understanding these interactions is crucial for evolutionary studies.

Purpose of the Study:

  • To investigate the population-genetic consequences of subdivision under genic selection.
  • To relate a structured population to an equivalent idealized panmictic population.
  • To explain how allele fixation probabilities are maintained despite population subdivision.

Main Methods:

  • Modeling a structured population using Wright's island model.
  • Analyzing the relationship between the structured population and an equivalent Wright-Fisher population.

Related Experiment Videos

  • Deriving effective population size (N(e)) and effective selection coefficient (s(e)).

    • Main Results:

    • A subdivided population with genic selection can be represented by an equivalent panmictic population.
    • The effective population size (N(e)) of the equivalent panmictic population is larger than the actual population size.
    • The effective selection coefficient (s(e)) in the equivalent population is smaller than the actual selection coefficient (s).

    Conclusions:

    • Population subdivision increases effective population size (N(e)) but decreases the effective selection coefficient (s(e)).
    • The product of N(e) and s(e) remains constant, explaining why allele fixation probabilities are unaffected by subdivision.
    • This provides a unified framework for understanding selection and drift in structured populations.