Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Systemic capillary leak syndrome. Case report.

D D Sabbadini1, R Peressutti, A Di Silvestre

  • 1Second Division of Anesthesia Resuscitation and Antalgic Therapy, Santa Maria della Misericordia Hospital, Udine, Italy. dariodavide.sabbadini@poste.it

Minerva Anestesiologica
|February 15, 2003
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Infectious bacterial symphysitis (purulent infection of the pubic symphysis) in a urological setting-a descriptive study and treatment algorithm].

Urologie (Heidelberg, Germany)·2025
Same author

Congenital cranial fasciitis of the ethmoid bone with extensive intracranial and facial involvement: a case report and review of the literature.

International journal of oral and maxillofacial surgery·2025
Same author

Erratum: Centrality-Dependent Modification of Jet-Production Rates in Deuteron-Gold Collisions at sqrt[s_{NN}]=200  GeV [Phys. Rev. Lett. 116, 122301 (2016)].

Physical review letters·2025
Same author

Multidisciplinary consensus-based statement on the current role of middle meningeal artery embolization (MMAE) in chronic SubDural hematoma (cSDH).

Brain & spine·2024
Same author

Plesiomonas shigelloides infection in newborn: case report and literature review.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery·2024
Same author

Correction: A novel oncogenic BTK isoform is overexpressed in colon cancers and required for RAS-mediated transformation.

Oncogene·2024

Systemic capillary leak syndrome (SCLS) is a rare condition causing shock, fluid shifts, and organ failure. Early diagnosis and treatment with theophylline and terbutaline may improve patient outcomes.

Area of Science:

  • Internal Medicine
  • Critical Care Medicine
  • Rare Diseases

Background:

  • Systemic capillary leak syndrome (SCLS) is a rare disorder characterized by recurrent episodes of hypotension, hemoconcentration, and hypoproteinemia.
  • It involves unexplained episodic capillary hyperpermeability, leading to fluid and protein shifting from the intravascular to the interstitial space.

Observation:

  • A 59-year-old male presented with unexplained shock, hemoconcentration, renal failure, and metabolic acidosis.
  • Initial resuscitation attempts with crystalloids and dopamine were unsuccessful.
  • Diagnostic imaging (CT, TEE, X-ray) and absence of infection/anaphylaxis were noted.

Findings:

  • The patient was resuscitated with aggressive fluid infusion and norepinephrine.
  • Diagnosis was based on prior shock episodes, hemoconcentration, and negative cardiopulmonary findings.

Related Experiment Videos

  • Monoclonal immunoglobulin G, kappa chain, in serum confirmed the SCLS diagnosis.

    • Implications:

    • SCLS must be considered in the differential diagnosis of idiopathic and anaphylactic shock.
    • Prophylactic treatment with theophylline and terbutaline may benefit SCLS patients.
    • This case highlights the diagnostic challenges and potential therapeutic strategies for SCLS.