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Solid-state nuclear magnetic resonance spectroscopy--pharmaceutical applications
Patrick A Tishmack1, David E Bugay, Stephen R Byrn
1SSCI, Inc., 3065 Kent Avenue, West Lafayette, Indiana 47906, USA.
Journal of Pharmaceutical Sciences
|February 15, 2003
Summary
Solid-state nuclear magnetic resonance (NMR) spectroscopy is crucial for characterizing pharmaceutical solids. This review details NMR methods for analyzing drug structure, molecular motion, resonance assignment, and internuclear distances.
Area of Science:
- Pharmaceutical Sciences
- Solid-state Chemistry
- Spectroscopy
Background:
- Solid-state nuclear magnetic resonance (NMR) spectroscopy is a vital tool in pharmaceutical research.
- Its application extends to the detailed characterization of both drug substances and finished dosage forms.
Purpose of the Study:
- This review synthesizes the application of solid-state NMR techniques in pharmaceutical analysis.
- It highlights methods for elucidating the structural and dynamic properties of pharmaceutical solids.
Main Methods:
- The review covers solid-state NMR methods for studying structure and conformation.
- Techniques for analyzing molecular motions, including relaxation and exchange spectroscopy, are discussed.
- Methods for resonance assignment (spectral editing, 2D correlation spectroscopy) and internuclear distance measurements are detailed.
Main Results:
- Solid-state NMR provides comprehensive insights into pharmaceutical solid-state properties.
- The discussed techniques enable detailed structural and dynamic characterization.
- NMR is effective for analyzing complex drug formulations.
Conclusions:
- Solid-state NMR spectroscopy is indispensable for the thorough characterization of pharmaceutical solids.
- These advanced NMR techniques offer powerful capabilities for drug development and quality control.
- Further application of these methods will advance pharmaceutical solid-state science.