Solid-state nuclear magnetic resonance spectroscopy--pharmaceutical applications
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Updated: Sep 27, 2026

High-Temperature and High-Pressure In situ Magic Angle Spinning Nuclear Magnetic Resonance Spectroscopy
Published on: October 9, 2020
Patrick A Tishmack1, David E Bugay, Stephen R Byrn
1SSCI, Inc., 3065 Kent Avenue, West Lafayette, Indiana 47906, USA.
Abstract:
Solid-state nuclear magnetic resonance (NMR) spectroscopy has become an integral technique in the field of pharmaceutical sciences. This review focuses on the use of solid-state NMR techniques for the characterization of pharmaceutical solids (drug substance and dosage form). These techniques include methods for (1) studying structure and conformation, (2) analyzing molecular motions (relaxation and exchange spectroscopy), (3) assigning resonances (spectral editing and two-dimensional correlation spectroscopy), and (4) measuring internuclear distances.
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