Artichoke leaf extract reduces mild dyspepsia in an open study

Area of Science:

• Gastroenterology
• Phytomedicine
• Clinical Nutrition

Background:

• Previous studies suggested high doses of standardized artichoke leaf extract (ALE) may alleviate dyspeptic symptoms.
• Further investigation was needed to confirm the efficacy of lower doses of ALE for dyspepsia management.

Purpose of the Study:

• To evaluate the effectiveness of a low-dose ALE in ameliorating dyspeptic symptoms.
• To assess the impact of ALE on the quality of life in individuals with dyspepsia.

Main Methods:

• An open, dose-ranging postal study involving healthy participants with self-reported dyspepsia.
• Participants received either 320 mg or 640 mg of ALE daily for 2 months.
• Dyspeptic symptoms and quality of life were assessed using the Nepean Dyspepsia Index and State-Trait Anxiety Inventory at baseline and after treatment.

Main Results:

• Both ALE dosage groups showed a significant reduction in all dyspeptic symptoms compared to baseline, with an average global dyspepsia score reduction of 40%.
• No significant differences were observed in primary outcome measures between the 320 mg and 640 mg groups.
• A greater reduction in state anxiety was noted in the higher dosage group (P = 0.03).
• Health-related quality of life significantly improved in both treatment groups.

Conclusions:

• Standardized artichoke leaf extract (ALE) demonstrates potential in alleviating upper gastrointestinal symptoms associated with dyspepsia.
• ALE treatment significantly enhances the quality of life for individuals experiencing dyspepsia.
• Both investigated doses of ALE are effective, with a potential added benefit of anxiety reduction at higher doses.