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Simultaneous kidney-pancreas transplantation in a patient with small lymphocytic lymphoma
A L Ramon Romero1, K Sudhakar Reddy, Thomas D Johnston
1Section of Transplantation, Department of Surgery, University of Kentucky, Lexington, KY 40536, USA.
Background:
Experience with organ transplantation in patients with indolent lymphoma is limited, and it is unknown how the natural history of the disease is altered by chronic immunosuppressive therapy.
Methods:
A patient with type 1 diabetes and renal failure who underwent simultaneous kidney-pancreas transplantation was found to have stage IV small lymphocytic lymphoma at the time of transplantation. He received quadruple immunosuppressive therapy using interleukin (IL)-2 receptor antibody, tacrolimus, mycophenolate mofetil, and prednisone.
Results:
Patient is doing well 3 years posttransplant with excellent graft function of both the kidney and pancreas without any evidence of progression of the disease.
Conclusion:
Indolent lymphoma should not be considered an absolute contraindication to organ transplantation.