Related Experiment Video
Updated: Jun 26, 2026
05:46
A Novel Inhalation Mask System to Deliver High Concentrations of Nitric Oxide Gas in Spontaneously Breathing Subjects
Published on: May 4, 2021
Exhaled nitric oxide in asthma: from bench to bedside
Christopher A Bates1, Philip E Silkoff
1Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA.
The Journal of Allergy and Clinical Immunology
|February 18, 2003
Summary
Exhaled nitric oxide (NO) shows promise as a noninvasive marker for diagnosing and managing asthma. This research reviews its potential to guide treatment and predict asthma exacerbations in clinical practice.
Area of Science:
- Pulmonary Medicine
- Biomarkers
- Respiratory Research
Background:
- Exhaled nitric oxide (NO) is a well-researched noninvasive marker for airway inflammation.
- Over 600 publications highlight its use in research settings.
- Translating this marker to clinical practice is an active area of investigation.
Purpose of the Study:
- To review the latest research on exhaled NO in asthma.
- To explore the clinical applicability of exhaled NO from research to patient care.
- To assess its role in asthma diagnosis, therapy monitoring, symptom evaluation, and exacerbation prediction.
Main Methods:
- Literature review of studies on exhaled nitric oxide (NO) in asthma.
- Analysis of evidence for diagnostic, therapeutic, and prognostic applications.
- Synopsis of research findings on clinical utility.
Main Results:
- Exhaled NO demonstrates applicability in diagnosing asthma.
- It aids in monitoring patient response to asthma therapies.
- It helps evaluate current symptom control and predict asthma exacerbations.
Conclusions:
- Exhaled nitric oxide (NO) has a significant role in the clinical evaluation and treatment of asthma.
- The evidence supports its transition from research to bedside application.
- Further integration of exhaled NO can optimize asthma management strategies.
Related Concept Videos
01:28Nitric Oxide Signaling Pathway
Nitric oxide (NO), an inorganic gas, acts as a potent second messenger in most animal and plant tissues. NO diffuses out of the cells that produce it and enters the neighboring cells to generate a downstream response. NO synthase (NOS) catalyzes NO production by the deamination of the amino acid arginine. There are three isoforms of NOS. Endothelial cells have endothelial NOS (eNOS), nerve and muscle cells have neuronal NOS (nNOS), and macrophages produce inducible NOS (iNOS) upon exposure to...
01:20Asthma: Pathogenesis and Management
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
01:26Asthma-II: Pathophysiology and Classification
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
01:30Asthma-IV: Diagnostic and Management
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
01:28Asthma I: Introduction
Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
01:13Asthma III: Clinical Manifestations
Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...