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Synthesis and cytotoxicity of podophyllotoxin analogues modified in the A ring
Angeles Castro1, José M Miguel del Corral, Marina Gordaliza
1Departamento de Química Farmacéutica, Facultad de Farmacia, Universidad de Salamanca, 37007 Salamanca, Spain. macg@usal.es
European Journal of Medicinal Chemistry
|February 21, 2003
Abstract:
Several podophyllotoxin derivatives lacking the methylenedioxy group or with different functionalization of the A-ring of the cyclolignan skeleton have been prepared and evaluated for their cytotoxic activities on four neoplastic cell lines (P-388, A-549, HT-29 and MEL-28). Most of them maintained their cytotoxicity at the microM level.