Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Development of the monosynaptic stretch reflex circuit.

Hsiao-Huei Chen1, Simon Hippenmeyer, Silvia Arber

  • 1Department of Neurobiology, University of Pittsburgh Medical School, 3500 Terrace Street, Pittsburgh, PA 15261, USA.

Current Opinion in Neurobiology
|February 21, 2003
PubMed
Summary

This study details the development of the spinal monosynaptic reflex, highlighting the roles of transcription factors, neuregulin 1, and neurotrophin 3 in sensory neuron and muscle spindle differentiation and connectivity.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A 3'UTR polymorphism disrupts IRF2BP2 autoregulation through an eIF4H translational enhancer.

Frontiers in genetics·2026
Same author

Tracing cell lineages in the developing brain: Insights from mosaic analysis and clone-resolved transcriptomics.

Current opinion in genetics & development·2026
Same author

Critical role of cell competition in gliomagenesis.

bioRxiv : the preprint server for biology·2026
Same author

Simultaneous detection of small and large variants enhances the diagnosis of rare diseases using full genome sequencing.

Human molecular genetics·2026
Same author

Basal ganglia-brainstem interactions.

Current biology : CB·2025
Same author

Reduction of neuronal activity mediated by blood-vessel regression in the adult brain.

Nature communications·2025

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Molecular Biology

Background:

  • The development of the spinal monosynaptic reflex is crucial for motor control.
  • Understanding the molecular mechanisms underlying this process is essential for addressing neurological disorders.

Purpose of the Study:

  • To elucidate the key molecular players and signaling pathways involved in the development of the spinal monosynaptic reflex.
  • To investigate the roles of specific transcription factors and signaling molecules in sensory neuron and muscle spindle differentiation and spinal cord connectivity.

Main Methods:

  • Analysis of transcription factor families (Neurogenin, Runt, ETS, LIM) in sensory neuron specification.
  • Investigation of neuregulin 1 and ErbB receptor signaling in muscle spindle differentiation.

Related Experiment Videos

  • Examination of retrograde signals and neurotrophin 3 in establishing reflex circuit connectivity.

    • Main Results:

    • Transcription factors orchestrate the sequential specification of dorsal root ganglia sensory neuron subtypes.
    • Neuregulin 1 signaling is critical for initiating muscle spindle differentiation.
    • Retrograde signals and neurotrophin 3 play vital roles in late connectivity and synaptic strength regulation within the spinal cord.

    Conclusions:

    • The development of the spinal monosynaptic reflex involves a complex interplay of transcription factors, growth factors, and retrograde signaling.
    • These molecular mechanisms ensure the precise formation and functional maturation of sensory-motor circuits.