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Abstract:
In an epidemiological study of 3,485 selected individuals in Tucson, aerosol usage appears to be correlated to prevalence of respiratory symptoms. This effect persists after adjusting age and smoking to the prevalence rates for symptoms and appears to exist for specific types of aerosols. Further specification and clarification of these relationships are needed in the epidemiological survey. Critical evaluation within in vitro and in vivo models is of great importance. It is concluded that the propellants, the ingredients of the application, and the combination elements in different circumstances must be studied toxicologically to determine the mechanism and extent of specific actions on organisms.