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Related Experiment Videos

Brain tissue volume changes in relapsing-remitting multiple sclerosis: correlation with lesion load.

Mario Quarantelli1, Andrea Ciarmiello, Vincenzo Brescia Morra

  • 1Biostructure and Bioimaging Institute, National Council for Research, Building 10, Via Pansini 5, 80131 Naples, Italy. quarante@unina.it

Neuroimage
|February 22, 2003
PubMed
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Multiple sclerosis patients show reduced gray matter and increased cerebrospinal fluid, with abnormal white matter correlating to gray matter loss. Disease duration, not brain volume changes, impacts disability scores.

Area of Science:

  • Neuroimaging
  • Neurology
  • Radiology

Background:

  • Relapsing-remitting multiple sclerosis (RR-MS) is characterized by demyelination and neurodegeneration.
  • Accurate in vivo quantification of brain tissue volumes is crucial for understanding MS pathophysiology.
  • Previous studies have focused on specific tissue types, lacking a comprehensive multiparametric approach.

Purpose of the Study:

  • To simultaneously measure and analyze in vivo volumes of gray matter (GM), normal white matter (WM), abnormal white matter (aWM), and cerebrospinal fluid (CSF) in RR-MS patients.
  • To assess the relationships between these tissue volumes and their correlation with clinical parameters like EDSS and disease duration.
  • To compare brain tissue volumes in RR-MS patients with normal volunteers (NV).

Main Methods:

Related Experiment Videos

  • Unsupervised multiparametric segmentation of brain MR images from 50 RR-MS patients and 54 NV.
  • Calculation of fractional tissue volumes (fGM, fWM, faWM, fCSF) normalized to intracranial volume.
  • Age-correction of fractional volumes based on data from normal volunteers.

Main Results:

  • MS patients exhibited significantly reduced fractional gray matter (fGM) and increased fractional cerebrospinal fluid (fCSF) compared to NV.
  • No significant difference in fractional normal white matter (fWM) was observed between groups.
  • Fractional abnormal white matter (faWM) showed an inverse correlation with fGM and a direct correlation with fCSF.
  • Disease duration significantly correlated with EDSS, but no significant relationship was found between fractional volumes and EDSS or disease duration.

Conclusions:

  • Brain atrophy in RR-MS is primarily driven by gray matter loss, which is associated with abnormal white matter accumulation.
  • These volumetric changes do not appear to significantly influence the Expanded Disability Status Scale (EDSS) score.
  • Disease duration is a more significant predictor of disability in RR-MS than the measured brain tissue volume changes.