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[Combined administration of mexidol and anti-arrhythmia agents]
A A Kotliarov1, L D Smirnov, L E Smirnova
1Department of Clinical Therapy, Mordvinian State University, ul. Ul'yanova 26, Saransk, Mordvinia, 430003 Russia.
Eksperimental'Naia I Klinicheskaia Farmakologiia
|February 25, 2003
Abstract:
The influence of mexidol on the acute toxicity and electrophysiological effects of nibentan, propranolol, and verapamil was experimentally studied. It was found that mexidol potentiates the ability of propranolol and verapamil to inhibit automatism of the sinus node and suppresses the ability of all the three drugs to increase the refractory period of myocardium. It is suggested that these effects are related to the action of mexidol upon ion channels.