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[Effect of interferon-alpha on the platelet aggregation and cyclic nucleotide system in chronic viral hepatitis]

A V Iagoda1, P V Koroĭ

  • 1Department of Internal Disorders, State Medical Academy, ul. Mira 310, Stavropol, 355017 Russia.

Eksperimental'Naia I Klinicheskaia Farmakologiia
|February 25, 2003
PubMed

Insights

Cyclic nucleotide (CN) levels increase and platelet aggregation (PA) decreases in chronic viral hepatitis (CVH) and liver cirrhosis (LC). Interferon-alpha (IFN-alpha) shows a normalizing effect on platelet function in these patients.

Area of Science:

  • Hepatology
  • Hematology
  • Immunology

Background:

  • Chronic viral hepatitis (CVH) and liver cirrhosis (LC) are associated with altered platelet function.
  • Elevated cyclic nucleotide (CN) levels and reduced platelet aggregation (PA) are observed in patients with liver disease.

Purpose of the Study:

  • To investigate the relationship between platelet aggregation (PA) and cyclic nucleotide (CN) content in patients with chronic viral hepatitis (CVH) and liver cirrhosis (LC).
  • To evaluate the effect of interferon-alpha (IFN-alpha) on PA and CN levels in these patients.

Main Methods:

  • Studied 44 patients with CVH/LC and 10 healthy volunteers.
  • Measured PA and CN levels before and 6 hours after IFN-alpha administration.

Main Results:

  • CN content was elevated in CVH and highest in LC patients.
  • PA was reduced in CVH and lowest in LC patients.
  • IFN-alpha decreased CN in LC and low-PA CVH patients, while increasing it in high-PA CVH patients, normalizing platelet function.

Conclusions:

  • Platelet dysfunction in CVH and LC correlates with increased CN levels.
  • IFN-alpha demonstrates a therapeutic potential by normalizing platelet function in patients with CVH and LC.

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