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Related Experiment Videos

Breathing: rhythmicity, plasticity, chemosensitivity.

Jack L Feldman1, Gordon S Mitchell, Eugene E Nattie

  • 1Department of Neurobiology, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA 90095-1763, USA. feldman@ucla.edu

Annual Review of Neuroscience
|February 25, 2003
PubMed
Summary
This summary is machine-generated.

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Respiratory rhythm generation involves the preBötzinger Complex, not necessarily pacemaker neurons. Adaptive breathing plasticity, like serotonin-dependent long-term facilitation, and chemosensation of CO2 and pH are also reviewed.

Area of Science:

  • Neuroscience
  • Respiratory Physiology

Background:

  • Breathing is a fundamental physiological process crucial for survival.
  • Understanding the neural control of breathing is essential for addressing respiratory disorders.

Purpose of the Study:

  • To review recent advancements in three key areas of respiratory control research.
  • To explore the generation of respiratory rhythm, mechanisms of respiratory plasticity, and chemosensation of CO2 and pH.

Main Methods:

  • Review of current experimental findings and theoretical models.
  • Discussion of critical brainstem regions, neuronal populations, and molecular pathways involved in breathing control.

Main Results:

  • The preBötzinger Complex is identified as a critical site for respiratory rhythm generation, with pacemaker neurons potentially not essential.

Related Experiment Videos

  • Serotonin-dependent long-term facilitation following intermittent hypoxia serves as a model for adaptive respiratory plasticity.
  • Chemosensory neurons responsible for sensing CO2 and pH are distributed throughout the brainstem, with their collective roles under investigation.

    • Conclusions:

    • Significant progress has been made in understanding the neural basis of breathing.
    • Further research is needed to fully elucidate the complex mechanisms underlying respiratory rhythm generation, plasticity, and chemosensation.