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[Study on effects of scutellarin on scavenging reactive oxygen]
Hong Liu1, Xiangliang Yang, Linzhu Zhou
1Institute of Pharmacy, Huazhong University of Science & Technology, Wuhan 430074.
Zhong Yao Cai = Zhongyaocai = Journal of Chinese Medicinal Materials
|February 26, 2003
Abstract
Objective:
To study the antioxidative effects and its mechanism of scutellarin.
Methods:
Scavenging effects of scutellarin on hydroxyl radical (OH.) produced from 0-phenathroline-ascorbic acid system, super oxide anion radical (O2-.) produced from xanthine-xanthine oxidase-luminol system and hydrogen peroxide was studied by a chemiluminescence assay.
Results:
Scutellarin has a significant effect on scavenging hydroxyl radicals, super oxide anion radicals, hydrogen peroxide, their IC50 are 66 micrograms/ml, 1.3 micrograms/ml and 1.6 micrograms/ml respectively.
Conclusion:
Scutellarin is an efficiency antioxidant.