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Updated: Aug 19, 2026

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[The protein expression of p53 and bcl-2 in laryngeal squamous cell carcinoma]
1Department of Otolaryngology, First Affiliated Hospital, WCUMS, Chengdu 610041, China.
Objective:
To detect the relationship of p53 and bcl-2 gene to laryngeal carcinoma.
Methods:
p53 and bcl-2 protein expressions were examined in the specimens of 60 laryngeal carcinomas and 8 vocal cord polyps by immunohistochemistry method.
Results:
Overexpressions of p53 and bcl-2 were found in the laryngeal carcinoma specimens; the positive rates of p53 and bcl-2 protein expression were 61.7%(37/60) and 43.3%(26/60), respectively. Negative results were observed in all the vocal cord polyp specimens. The positive rates of p53 and bcl-2 expression were related to the histological grade and cervical lymphatic metastasis of laryngeal carcinoma but not related to clinical stage and tumor types.
Conclusion:
The results of this study support the hypothesis that p53 and bcl-2 gene may be involved in the apoptosis of laryngeal carcinoma and they may play an important role in the pathogenesis of laryngeal cancer.
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