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Updated: Aug 12, 2026

Isolation of Rat Portal Fibroblasts by In situ Liver Perfusion
Published on: June 29, 2012
[TGF beta 1 and ET-1 expression in the peripheral blood of patients with cirrhosis]
1Department of Internal Medicine, First Affiliated Hospital, WCUMS, Chengdu 610041, China.
Objective:
The aims of this study were to determine 1. the variation of blood TGF beta 1 and ET-1 in patients with liver cirrhosis; 2. the relationship of the blood TGF beta 1 and ET-1 with Child degree of liver function and the severity of esophageal varices.
Methods:
Peripheral blood samples were obtained from 72 patients and 24 normal controls. The blood levels of TGF beta 1 and ET-1 were measured by using a standard bioassay and the radioimmunoassay.
Results:
TGF beta 1 level (11.77 +/- 1.32 ng/ml) and ET-1 level (78.37 +/- 17.54 pg/ml) were significantly higher in the patients than those in controls(P < 0.05). The increase of the ET-1 in the patients is closely associated with Child degree of liver function (r = 0.94) and the severity of esophageal varices(r = 0.87). TGF beta 1 concentration is not associated with Child degree of liver function (r = 0.11) and the severity of esophageal varices (r = 0.03).
Conclusion:
TGF beta 1 and ET-1 may play an important role in the pathophysiologic process of cirrhosis. ET-1 concentration may reflect portal hypertension development.
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