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Expansion, Purification, and Functional Assessment of Human Peripheral Blood NK Cells
Published on: February 2, 2011
[The effect of AG490 on NK activity and lymphocyte transformation of PBMC]
1Department of Immunology, School of Basic Medical Sciences, WCUMS, Chengdu 610041, China.
Hua Xi Yi Ke Da Xue Xue Bao = Journal of West China University of Medical Sciences = Huaxi Yike Daxue Xuebao
|February 26, 2003
Abstract
Objective:
To examine the effect of AG490 on NK activity and lymphocyte transformation.
Methods:
Using MTT colorimetry to detect cell survival, NK activity and cell proliferation.
Results:
AG490 inhibited IL-2 and PHA induced peripheral blood mononuclear cell proliferation, and it inhibited NK activation.
Conclusion:
As an inhibitor of JAK, AG490 can influence the function of normal cells.
