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Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia
Published on: October 17, 2025
[Whipple's disease as a complication of chronic lymphocytic leukemia treated with fludarabine]
Małgorzata Kuliszkiewicz-Janus1, Rafał Małecki, Kazimierz Kuliczkowski
1Katedra i Klinika Hematologii i Chorób Rozrostowych AM we Wrocławiu.
Abstract:
The case of 53-year-old man who suffered from chronic lymphocytic leukemia since 1993 was presented. In the 6th year of treatment fludarabine was administered. Few days after administration of drug the patient developed watery diarrhoea not responding to treatment. We excluded both infectious etiological factors and infiltration of intestine in course of chronic lymphocytic leukemia. Histopathological examination with monoclonal antibodies and periodic acid-Schiff stain (PAS) revealed Whipple's disease as the reason of enteropathy. During 6 months diarrhoea caused extreme dyselectrolitemia, renal insufficiency and finally death of the patient.
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