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Related Experiment Videos

Partial laryngectomy after irradiation failure.

John Yiotakis1, Pelagia Stavroulaki, Thomas Nikolopoulos

  • 1Ear, Nose and Throat Department, Faculty of Medicine, University of Athens.

Otolaryngology--Head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
|February 26, 2003
PubMed
Summary

Salvage partial laryngectomy offers good oncologic outcomes and laryngeal function for early glottic cancer after radiation failure. Further research is needed for T2 supraglottic lesions.

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Area of Science:

  • Otolaryngology
  • Surgical Oncology
  • Radiation Oncology

Background:

  • Radiation therapy is a primary treatment for early glottic cancer, but has a substantial failure rate.
  • Salvage total laryngectomy has been the standard for radiation failure, with partial laryngectomy emerging as an alternative.
  • This study evaluates partial laryngectomy for radiation failure in laryngeal cancer, assessing oncologic results and morbidity.

Purpose of the Study:

  • To evaluate the oncologic outcomes and morbidity of salvage partial laryngectomy following radiation failure in early laryngeal cancer.
  • To compare the effectiveness of vertical laryngectomy versus horizontal-supraglottic laryngectomy in this patient population.

Main Methods:

  • A retrospective review of 27 patients with early-stage laryngeal carcinoma who underwent salvage partial laryngectomy after irradiation failure between 1984 and 1995.

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  • Procedures included vertical laryngectomy (18 patients) and horizontal-supraglottic laryngectomy (9 patients).
  • Mean follow-up was 4.1 years.

    • Main Results:

    • Local control rates were 77.7% for glottic lesions and 55.5% for supraglottic lesions.
    • Regional control was achieved in 100% of vertical laryngectomy patients and 77.7% of horizontal-supraglottic laryngectomy patients.
    • Overall survival rates were 88.8% for glottic lesions and 66.6% for supraglottic lesions.

    Conclusions:

    • Partial laryngectomy, particularly vertical laryngectomy, can achieve good oncologic control and preserve laryngeal function in early laryngeal cancer after radiation failure.
    • Horizontal-supraglottic laryngectomy had higher morbidity but satisfactory functional outcomes.
    • For T2 supraglottic lesions, outcomes were less satisfactory, necessitating further research into alternative or complementary treatments.