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Related Experiment Videos

Enzyme changes in lichen planus.

A Jarrett, K M Witham, J A Hardy

    Archiv Fur Dermatologische Forschung
    |July 18, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Histochemical analysis of lichen planus reveals reduced acid phosphatase and absent dendritic cells in active lesions. These findings, along with altered glucose-6-phosphate dehydrogenase and phospholipid reactions, offer new insights into lichen planus pathology.

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    Area of Science:

    • Dermatology
    • Histochemistry
    • Biochemistry

    Background:

    • Lichen planus is a common inflammatory condition affecting skin and mucous membranes.
    • Previous studies suggest potential metabolic derangements in lichen planus.
    • Understanding the biochemical changes in lichen planus is crucial for diagnosis and treatment.

    Purpose of the Study:

    • To investigate histochemical alterations in untreated lichen planus lesions.
    • To quantitatively assess enzyme activity and cellular changes in lichen planus.
    • To compare biochemical findings in lichen planus with normal epidermis and psoriasis.

    Main Methods:

    • Histochemical techniques were applied to untreated lichen planus skin samples.
    • Quantitative estimation of acid phosphatase activity in the transitional zone.

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  • Assessment of glucose-6-phosphate dehydrogenase, ATPase, and phospholipid reactions in epidermal layers.

    • Main Results:

    • A marked reduction in acid phosphatase activity was observed despite a thickened granular layer.
    • Elevated glucose-6-phosphate dehydrogenase activity was noted in the upper epidermis of active lesions.
    • Dendritic cells (ATPase reaction) were virtually absent in active lichen planus, and the horny layer showed dense phospholipid reactions.

    Conclusions:

    • Histochemical findings suggest significant metabolic and cellular alterations in lichen planus.
    • The observed changes in enzyme activity and cell presence differentiate lichen planus from normal epidermis and share similarities with psoriasis.
    • These results warrant further investigation into the potential role of metabolic errors in lichen planus pathogenesis.